SMD-3040

• Target:

  PROTACs|||Epigenetic Reader Domain

• Related Pathways:

  PROTAC|||Chromatin/Epigenetic

• Bioactivity:

  SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM), comprising an SMARCA2/4 ligand, a linker, and a VHL ligand. It exhibits excellent degradation selectivity for the SMARCA2 protein over the SMARCA4 protein and has demonstrated robust tumor growth inhibition in xenograft models [1].

• Smiles:

  CC1=C(C2=CC=C([C@@H](NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC([C@@H]4CC[C@@H](CN5CC6(CCC(N7C=C(C8=CC(C9=CC=CC=C9O)=NN=C8N)C=N7)CC6)C5)CC4)=O)C(C)(C)C)=O)=O)C)C=C2)SC=N1

• Molecular Formula:

  C52H66N10O5S

• Molecular Weight:

  943.21

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3033109-92-8