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SMD-3040

CAT: 0931-T79820-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T79820-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3033109-92-8
Target
PROTACs|||Epigenetic Reader Domain
Related Pathways
PROTAC|||Chromatin/Epigenetic
Bioactivity
SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM), comprising an SMARCA2/4 ligand, a linker, and a VHL ligand. It exhibits excellent degradation selectivity for the SMARCA2 protein over the SMARCA4 protein and has demonstrated robust tumor growth inhibition in xenograft models [1].
Smiles
CC1=C(C2=CC=C([C@@H](NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC([C@@H]4CC[C@@H](CN5CC6(CCC(N7C=C(C8=CC(C9=CC=CC=C9O)=NN=C8N)C=N7)CC6)C5)CC4)=O)C(C)(C)C)=O)=O)C)C=C2)SC=N1
Molecular Formula
C52H66N10O5S
Molecular Weight
943.21
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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Alternative Products

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MBS5821481SMD-3040
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HY-156568ASMD-3040 (TFA)
HY-156568B-01SMD-3040 (formate)
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HY-400685-01SMD-3040 intermediate-2
A23973-5SMD-3040 formate 5mg
A23973-50SMD-3040 formate 50mg
A23973-100SMD-3040 formate 100mg
HY-400342SMD-3040 intermediate-1

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