PBS-1086

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  PBS-1086 is a novel dual inhibitor of the canonical and noncanonical NF-?B pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and suppressing phosphorylation of the PDHK1 protein substrate PDHA1 in a panel of PTEN-deficient cell lines.

• Smiles:

  OC1C2C(O2)C(=O)C=C1NC(=O)C3=CC=4C(NC3=O)=CC=CC4

• Molecular Formula:

  C16H12N2O5

• Molecular Weight:

  312.28

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1246668-32-5