STF-1084

CAT: 0931-T207746-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T207746-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2298390-71-1
Target
Others|||PDE
Related Pathways
Metabolism|||Others
Bioactivity
STF-1084 is an inhibitor that cannot penetrate cells and targets ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) with an apparent Ki of 0.11 µM. It demonstrates selectivity for ENPP1 over ENPP2 and alkaline phosphatase (ALP) with apparent Kis of 5.5 and >100 µM, respectively, and does not affect a panel of 468 kinases at 1 µM. STF-1084 hinders the extracellular breakdown of cGAMP in ENPP1-overexpressing and cGAS-expressing 293T cells, with an IC50 of 0.340 µM, and enhances mRNA expression for the gene encoding IFN-? in CD14+ primary human peripheral blood mononuclear cells (PBMCs) when incubated with conditioned medium from ENPP1-overexpressing and cGAS-expressing 293T cells treated with STF-1084. In a live setting, STF-1084, when combined with ionizing radiation, elevates the proportion of tumor-associated CD11c+ cells among antigen-presenting cells (APCs) in a murine mammary cancer model (4T1) .
Smiles
O=P(O)(O)CCC1CCN(C=2N=CN=C3C=C(OC)C(OC)=CC32)CC1
Molecular Formula
C17H24N3O5P
Molecular Weight
381.36
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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