COX-2-IN-51

CAT: 0931-T204857-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T204857-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3064260-49-4

Target

COX, NF-κB

Related Pathways

NF-κB, Neuroscience, Immunology/Inflammation

Bioactivity

COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.

Smiles

FC1=CC=C2OC(OCCC3=CSC=C3)(C(=CC2=C1)C=4C=CC(OC)=CC4)C(F)(F)F

Molecular Formula

C23H18F4O3S

Molecular Weight

450.446

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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COX-2-IN-51

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