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JH-FK-08

CAT: 0931-T204721-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204721-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Interleukin, Antifungal
Related Pathways
Immunology/Inflammation, Microbiology/Virology
Bioactivity
JH-FK-08 is an inhibitor of the serine/threonine-specific phosphatase enzyme calcineurin (calcium-dependent phosphatase) . It demonstrates antifungal activity, effectively inhibiting C. neoformans with a MIC80 of 0.8 μg/mL. Additionally, JH-FK-08 exhibits immunosuppressive properties by inhibiting IL-2 expression with an IC50 of 42.6 nM, and shows anti-infective activity in mouse models.
Smiles
CC[C@@H]\1/C=C(/C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](C/C1=N/NC(=O)OC)O)C)/C(=C/C4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC)C)\C
Molecular Formula
C45H73N3O13
Molecular Weight
864.073
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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