EGFR-IN-145

CAT: 0931-T204326-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T204326-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

852407-49-9

Target

EGFR

Related Pathways

Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling

Bioactivity

EGFR-IN-145 (compound 7c) is an EGFR kinase inhibitor. At a concentration of 20 μM, it inhibits wild-type EGFR kinase by 52.7%.

Smiles

FC1=CC=C(C=C1)CNC=2N=CN=C3SC4=C(C32)CCCC4

Molecular Formula

C17H16FN3S

Molecular Weight

313.392

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

N-(4-Fluorobenzyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine

CAS Number	852407-49-9
PubChem CID	2563183
IUPAC Name	N-[(4-fluorophenyl)methyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine
Molecular Formula	C17H16FN3S
Molecular Weight	313.4
XLogP	4.7
Topological Polar Surface Area	66.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Heavy Atom Count	22
Formal Charge	0
Complexity	375

SMILES

C1CCC2=C(C1)C3=C(N=CN=C3S2)NCC4=CC=C(C=C4)F

InChI

InChI=1S/C17H16FN3S/c18-12-7-5-11(6-8-12)9-19-16-15-13-3-1-2-4-14(13)22-17(15)21-10-20-16/h5-8,10H,1-4,9H2,(H,19,20,21)

InChIKey

CFNNRUHQKQNOMT-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 852407-49-9

CID: 2563183

Formula: C17H16FN3S

MW: 313.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	313.4
XLogP3	4.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	313.10489686
Monoisotopic Mass	313.10489686
Topological Polar Surface Area	66.1 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	375
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
T70541-01	IS-145
TP3555-01	OP-145
T25825-01	MMP-145
T12074-01	ML 145
T78752-01	Antibacterial agent 145
T85706-01	Antitumor agent-145
T83849-01	OP-145 TFA
T74274-01	LEB-03-145
T211861-01	EGFR-IN-166
T211095-01	EGFR-IN-163

Alternative Products

Catalog	Name
HY-171252-01	EGFR-IN-145
GTR19209537-01	IS-145
CL-0566	MARC-145 [Marc-145; Marc 145; Marc145] Cell Line
FP43074-01	IPI 145
2445-5	IPI-145
MBS3844405-01	ML 145
ABC-TC0003	145-2C11
TRC-J211535-100MG	JWH-145
C0019004	DU 145
sc-65759	AChRγ (145)

EGFR-IN-145

Chemical Information

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