NF-?B/MAPK-IN-2

• Target:

  NF-?B|||p38 MAPK

• Related Pathways:

  NF-?B|||MAPK

• Bioactivity:

  NF-?B/MAPK-IN-2 (compound 14) is a potent inhibitor of NF-?B and MAPK pathways. It effectively reduces the protein expression levels of p-p65, p-I?B, p-p38, p-JNK, and p-ERK. This compound decreases the release of TNF-? and IL-6 induced by LPS and inhibits the nuclear translocation of p65 and c-Fos. NF-?B/MAPK-IN-2 shows potential for research in sepsis.

• Smiles:

  CCOC (=O) C1=NOC2=C1C[C@]3 ([C@H] ([C@]2 (C) COC (=O) CCC (=O) N4CCOCC4) CC[C@@]5 ([C@@H]3CC=C6[C@]5 (CC[C@@]7 ([C@H]6CC (CC7) (C) C) C (=O) OCC8=CC=CC=C8) C) C) C

• Molecular Formula:

  C49H66N2O9

• Molecular Weight:

  827.056

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C