NF-?B/MAPK-IN-2

• Target :

  NF-?B|||p38 MAPK

• Related Pathways :

  NF-?B|||MAPK

• Bioactivity :

  NF-?B/MAPK-IN-2 (compound 14) is a potent inhibitor of NF-?B and MAPK pathways. It effectively reduces the protein expression levels of p-p65, p-I?B, p-p38, p-JNK, and p-ERK. This compound decreases the release of TNF-? and IL-6 induced by LPS and inhibits the nuclear translocation of p65 and c-Fos. NF-?B/MAPK-IN-2 shows potential for research in sepsis.

• Smiles :

  CCOC(=O)C1=NOC2=C1C[C@]3([C@H]([C@]2(C)COC(=O)CCC(=O)N4CCOCC4)CC[C@@]5([C@@H]3CC=C6[C@]5(CC[C@@]7([C@H]6CC(CC7)(C)C)C(=O)OCC8=CC=CC=C8)C)C)C

• Molecular Formula :

  C49H66N2O9

• Molecular Weight :

  827.056

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C