Tyk2-IN-20

• Target:

  JAK

• Related Pathways:

  JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Stem Cells|||Chromatin/Epigenetic

• Bioactivity:

  Tyk2-IN-20 (Example 289) is an effective inhibitor of Tyk2 with an IC50 value below 5 nM. Additionally, it inhibits JAK1, JAK2, and JAK3 with IC50 values under 100 nM. This compound is utilized for the research of inflammatory diseases.

• Smiles:

  C (#N) [C@@]1 (C (=O) N (C[C@H]1C) C=2C=3N (C=C (N2) C4=CN (N=C4) C5CC6 (C5) COC6) N=CC3) C7CC7

• Molecular Formula:

  C24H25N7O2

• Molecular Weight:

  443.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3058568-08-1