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MORF-627

CAT: 0931-T203397-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203397-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2412688-16-3
Target
Integrin, TGF-beta/Smad
Related Pathways
Stem Cells, Cytoskeletal Signaling
Bioactivity
MORF-627 is an orally active selective inhibitor of integrin αvβ6 (integrinαvβ6), with an IC50 of 9.2 nM as measured in a human serum ligand binding assay. It effectively inhibits αvβ6-mediated activation of TGF-β1 with an IC50 of 2.63 nM and suppresses SMAD2/3 phosphorylation, showing an IC50 of 8.3 nM. Additionally, MORF-627 ameliorates bleomycin-induced pulmonary fibrosis in mice.
Smiles
[C@@H](C(O)=O)(C1=C([C@@H]2CCC3(CC3)CO2)C=CC(F)=C1)N4C[C@H](OCCCCC=5NC=6C(=CC5)CCCN6)CC4
Molecular Formula
C31H40FN3O4
Molecular Weight
537.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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