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MORF-627

CAT: 0804-HY-149136-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-149136-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MORF-627 is a selective, orally active inhibitor for integrin αvβ6 with an IC50 of 9.2 nM measuring by human serum ligand binding assay. MORF-627 inhibits αvβ6-mediated TGF-β1 activation with an IC50 of 2.63 nM, inhibits SMAD2/3 phosphorylation with an IC50 of 8.3 nM. MORF-627 ameliorates the Bleomycin -induced mouse lung fibrosis[1].
CAS Number
2412688-16-3
UNSPSC
12352005
Target
Integrin; TGF-beta/Smad
Type
Reference compound
Related Pathways
Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/morf-627.html
Smiles
OC([C@@H](N1C[C@@H](CC1)OCCCCC(N2)=CC=C3C2=NCCC3)C4=C(C=CC(F)=C4)[C@@H]5CCC6(CO5)CC6)=O
Molecular Formula
C31H40FN3O4
Molecular Weight
537.67
References & Citations
[1]Harrison BA, et al., The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin αvβ6 Inhibitor for Fibrosis. J Med Chem. 2024 Nov 14;67 (21) :18656-18681.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
αvβ6

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