STAT3-IN-39

• Target:

  STAT

• Related Pathways:

  JAK/STAT signaling|||Stem Cells

• Bioactivity:

  STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 ?M in NIH-3T3 cells. It hinders TGF-?1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.

• Smiles:

  O=C(C1=CC=2C=CC=CC2S1(=O)=O)N3CCN(CC4=CC(F)=C(F)C=C4F)CC3

• Molecular Formula:

  C20H17F3N2O3S

• Molecular Weight:

  422.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3037596-35-0