BM-1244

• Target:

  Others|||Apoptosis|||PARP|||Bcl-2 Family|||Caspase

• Related Pathways:

  Others|||Proteases/Proteasome|||DNA Damage/DNA Repair|||Apoptosis|||Chromatin/Epigenetic

• Bioactivity:

  BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM[1].

• Smiles:

  CC(C)n1c(C)c(c(c1-c1ccc(Cl)cc1)-c1cc(F)cc(c1)N1CCN(CC1)c1ccc(NS(=O)(=O)c2ccc(N[C@H](CCN3CCC(CC3)C(O)=O)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)cc1)S(C)(=O)=O

• Molecular Formula:

  C54H59ClF4N6O8S4

• Molecular Weight:

  1159.78

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1619923-32-8