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BM-1244

CAT: 0931-T36884-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T36884-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1619923-32-8
Target
Others|||Apoptosis|||PARP|||Bcl-2 Family|||Caspase
Related Pathways
Others|||Proteases/Proteasome|||DNA Damage/DNA Repair|||Apoptosis|||Chromatin/Epigenetic
Bioactivity
BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM[1].
Smiles
CC(C)n1c(C)c(c(c1-c1ccc(Cl)cc1)-c1cc(F)cc(c1)N1CCN(CC1)c1ccc(NS(=O)(=O)c2ccc(N[C@H](CCN3CCC(CC3)C(O)=O)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)cc1)S(C)(=O)=O
Molecular Formula
C54H59ClF4N6O8S4
Molecular Weight
1159.78
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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