BM-1244

• Target:

  Others|||Apoptosis|||PARP|||Bcl-2 Family|||Caspase

• Related Pathways:

  Others|||Proteases/Proteasome|||DNA Damage/DNA Repair|||Apoptosis|||Chromatin/Epigenetic

• Bioactivity:

  BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM[1].

• Smiles:

  CC (C) n1c (C) c (c (c1-c1ccc (Cl) cc1) -c1cc (F) cc (c1) N1CCN (CC1) c1ccc (NS (=O) (=O) c2ccc (N[C@H] (CCN3CCC (CC3) C (O) =O) CSc3ccccc3) c (c2) S (=O) (=O) C (F) (F) F) cc1) S (C) (=O) =O

• Molecular Formula:

  C54H59ClF4N6O8S4

• Molecular Weight:

  1159.78

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1619923-32-8