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PROTAC SMARCA2 degrader-32

CAT: 0931-T203233-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203233-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3033586-50-1
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
PROTAC SMARCA2 degrader-32 (Compound 27) is an effective degrader of SMARCA2, with a DC50 of 1.3 nM. It inhibits the proliferation of lung cancer cells NCI-H838 with a GI50 of 34 nM.
Smiles
CC1(C)C=2N(C=3C1=CC=C(C3)C4CCN(C[C@@H]5CC[C@H](CC5)C6=CN([C@H](C(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)C(C)(C)C)N=N6)CC4)C=%10C(C(=O)N2)=C(Cl)C=CC%10
Molecular Formula
C54H64ClN9O4S
Molecular Weight
970.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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