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H3B-616

CAT: 931-T202811-01Size: 10 mgDry Ice: NoHazardous: No
10 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2468199-06-4
Bioactivity
H3B-616, as a powerful allosteric inhibitor of Carbamoyl phosphate synthetase 1 (CPS1) with an IC50 of 66 nM, targets CPS1, identified as a potential synthetic lethal target in LKB1-deficient non-small cell lung cancer. This overexpression of CPS1 facilitates pyrimidine synthesis in these cancer cells.
Smiles
C(=O)(C=1C=C2C(=CC1)C=CN2)N3C[C@@H](C)N(C(=O)C4=C(F)C=C(OC)C=C4)[C@H](C)C3
Molecular Formula
C23H24FN3O3
Molecular Weight
409.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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