H3B-616

• Bioactivity :

  H3B-616, as a powerful allosteric inhibitor of Carbamoyl phosphate synthetase 1 (CPS1) with an IC50 of 66 nM, targets CPS1, identified as a potential synthetic lethal target in LKB1-deficient non-small cell lung cancer. This overexpression of CPS1 facilitates pyrimidine synthesis in these cancer cells.

• Smiles :

  C(=O)(C=1C=C2C(=CC1)C=CN2)N3C[C@@H](C)N(C(=O)C4=C(F)C=C(OC)C=C4)[C@H](C)C3

• Molecular Formula :

  C23H24FN3O3

• Molecular Weight :

  409.45

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2468199-06-4