H3B-616

• Bioactivity:

  H3B-616, as a powerful allosteric inhibitor of Carbamoyl phosphate synthetase 1 (CPS1) with an IC50 of 66 nM, targets CPS1, identified as a potential synthetic lethal target in LKB1-deficient non-small cell lung cancer. This overexpression of CPS1 facilitates pyrimidine synthesis in these cancer cells.

• Smiles:

  C (=O) (C=1C=C2C (=CC1) C=CN2) N3C[C@@H] (C) N (C (=O) C4=C (F) C=C (OC) C=C4) [C@H] (C) C3

• Molecular Formula:

  C23H24FN3O3

• Molecular Weight:

  409.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2468199-06-4