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H3B-616

CAT: 0013-GTR19241721-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19241721-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
H3B-616 is a potent, allosteric CPS1 inhibitor (IC50 = 66 nM) targeting a synthetic lethal vulnerability in LKB1-deficient NSCLC. It disrupts pyrimidine synthesis and has demonstrated efficacy in relevant in vitro and in vivo cancer models for research use.
CAS Number
2468199-06-4
Smiles
C (=O) (C=1C=C2C (=CC1) C=CN2) N3C[C@@H] (C) N (C (=O) C4=C (F) C=C (OC) C=C4) [C@H] (C) C3
Molecular Formula
C23H24FN3O3
Molecular Weight
409.45
Storage Conditions
-20°C
Notes
For research use only.

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