H3B-968

• Target:

  DNA/RNA Synthesis

• Related Pathways:

  DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

• Bioactivity:

  H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, targeting its helicase, ATPase, and exonuclease activities. While WRN is known for its synthetic lethal activity in cancer studies, H3B-968 specifically inhibits WRN's helicase function through competitive ATP antagonism [1].

• Smiles:

  S(NCC(NC1=CC=C(CC)C=C1)=O)(=O)(=O)C=2N=C(C=C(C(F)(F)F)N2)C3=CC=C(OC(F)(F)F)C=C3

• Molecular Formula:

  C22H18F6N4O4S

• Molecular Weight:

  548.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2912294-90-5