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H3B-968

CAT: 0931-T78938-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T78938-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2912294-90-5
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, targeting its helicase, ATPase, and exonuclease activities. While WRN is known for its synthetic lethal activity in cancer studies, H3B-968 specifically inhibits WRN's helicase function through competitive ATP antagonism [1].
Smiles
S(NCC(NC1=CC=C(CC)C=C1)=O)(=O)(=O)C=2N=C(C=C(C(F)(F)F)N2)C3=CC=C(OC(F)(F)F)C=C3
Molecular Formula
C22H18F6N4O4S
Molecular Weight
548.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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