CQ-Mito

CAT: 0931-MF-0110755-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0110755-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Ferroptosis|||Apoptosis|||GPCR|||MMP|||Arrestin|||Endogenous Metabolite
Related Pathways
Endocrinology/Hormones|||Apoptosis|||GPCR/G Protein|||Proteases/Proteasome|||Metabolism
Bioactivity
CQ-Mito, a derivative of CQ, demonstrates excellent phototherapeutic efficacy with a PI value of 167. This compound induces cell death through mechanisms such as apoptosis and ferroptosis. It mediates mitochondrial dysfunction, characterized by alterations in mitochondrial morphology and loss of MMP. Additionally, CQ-Mito effectively inhibits tumor growth in 3D multicellular tumor spheroid models.
Smiles
CCN(CC)C1=CC=C2C(OC(C(C3=NC(C=CC(OCC4=CN(CCC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)N=N4)=C8)=C8C(N3)=O)=C2)=O)=C1.[Br-]
Molecular Formula
C45H42BrN6O4P
Molecular Weight
841.73
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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