Phenacetin

CAT: 0013-GTR19161203-01Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19161203-01Size:500 mg

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Description

Phenacetin is a non-opioid analgesic without anti-inflammatory properties. Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. Phenacetin is an antipyretic, acting on the brain to decrease the temperature set point. Phenacetin is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia. (In Vitro) :Phenacetin shows inhibitory activity for COX-3 with an IC50 value of 102 μM in insect cells .Phenacetin is a substrate widely used as an in vitro and in vivo probe to measure the activity of CYP1A2, because the metabolism of phenacetin to acetaminophen is thought to be a selective CYP1A2-mediated reaction. (In Vivo) :Phenacetin exhibits elimination half-life (rat 2.06 h) and Cmax (6,728.3 μg/L) following oral administration (rat 20 mg/kg) .

CAS Number

62-44-2

Product Name Alternative

P-Acetophenetidide | 4′-Ethoxyacetanilide | NSC 7651

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

Ethanol: 36 mg/mL (200.87 mM) ; DMSO: 36 mg/mL (200.87 mM)

Smiles

CC (NC1=CC=C (OCC) C=C1) =O

Molecular Formula

C10H13NO2

Molecular Weight

179.22

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

N- (4-Ethoxyphenyl) acetamide

Chemical Information

Phenacetin

Phenacetin can cause cancer according to California Labor Code.

CAS Number	62-44-2
PubChem CID	4754
IUPAC Name	N-(4-ethoxyphenyl)acetamide
Molecular Formula	C10H13NO2
Molecular Weight	179.22
XLogP	1.6
Topological Polar Surface Area	38.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Heavy Atom Count	13
Formal Charge	0
Complexity	162

SMILES

CCOC1=CC=C(C=C1)NC(=O)C

InChI

InChI=1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)

InChIKey

CPJSUEIXXCENMM-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 62-44-2

CID: 4754

Formula: C10H13NO2

MW: 179.22

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	179.22
XLogP3	1.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	179.094628657
Monoisotopic Mass	179.094628657
Topological Polar Surface Area	38.3 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	162
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Catalog	Name
561575	Phenacetin

Phenacetin

Chemical Information

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