CDK-TCIP1

• Target:

  Bcl-2 Family|||CDK

• Related Pathways:

  Cell Cycle/Checkpoint|||Apoptosis

• Bioactivity:

  CDK-TCIP1 is a bivalent molecule that links the CDK9 inhibitor SNS-032 with the BCL6 ligand BI3812. It effectively and specifically kills cells overexpressing BCL6, with an EC50 of 7.7 nM for SUDHL5 cells.

• Smiles:

  O=C1C(OCC(=O)NC)=CC=2C=C(C=C(OC)C2N1C)NC3=NC(=NC=C3Cl)N4CCC(C(=O)NCCCCCCC(=O)N5CCC(C(=O)NC6=NC=C(S6)SCC7=NC=C(O7)C(C)(C)C)CC5)CC4

• Molecular Formula:

  C48H62ClN11O8S2

• Molecular Weight:

  1020.66

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3008612-35-6