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Antiproliferative agent-59

CAT: 0931-T201186-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201186-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, Microtubule Associated
Related Pathways
Apoptosis, Cytoskeletal Signaling
Bioactivity
Antiproliferative agent-59 (Compound 14u) acts as an inhibitor of tubulin polymerization. Demonstrating anticancer activity in Huh7, SGC-7901, and MCF-7 cell lines, this compound achieves IC50 values of 0.03, 0.18, and 0.13 μM, respectively. Additionally, it arrests the cell cycle at the G2/M phase and induces apoptosis in Huh7 cells. In a xenograft mouse model utilizing Huh7 cells, Antiproliferative agent-59 exhibits antitumor effects against hepatocellular carcinoma without significant toxicity.
Smiles
FC(F)(F)C=1C=C(OC)C=C(C1)NC2=NC=CC(=N2)C=3C=NN4N=C(OC)C=CC34
Molecular Formula
C26H22N2O3
Molecular Weight
410.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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