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Antiproliferative agent-59

CAT: 0804-HY-168102Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168102Size:1 Each
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Description
Antiproliferative agent-59 (Compound 14u) is an inhibitor for tubulin polymerization. Antiproliferative agent-59 exhibits antiproliferative activities against cancer cells Huh7, SGC-7901, and MCF-7 with IC50 of 0.03, 0.18, and 0.13μM. Antiproliferative agent-59 arrests the cell cycle at G2/M phase and induces apoptosis in Huh7 cell. Antiproliferative agent-59 exhibits antitumor efficacy against liver cancer in Huh7 xenograft mouse models, without significant toxicity[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antiproliferative-agent-59.html
Smiles
COC1=C(OC)C(OC)=CC(C2=CC=NC3=CC=C(C4=CC=CC5=C4C=CN5)C=C23)=C1
Molecular Formula
C26H22N2O3
Molecular Weight
410.46
References & Citations
[1]Xu Q, et al., Discovery and biological evaluation of 6-aryl-4- (3,4,5-trimethoxyphenyl) quinoline derivatives with promising antitumor activities as novel colchicine-binding site inhibitors. Eur J Med Chem. 2024 Sep 19;279:116869.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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