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PROTAC ALK degrader-3

CAT: 0931-T201107-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201107-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
ALK, PROTACs
Related Pathways
Tyrosine Kinase/Adaptors, PROTAC, Angiogenesis
Bioactivity
PROTAC ALK degrader-3 (4B) is an orally active PROTAC-based ALK degrader, efficiently inducing sustained degradation of ALK fusion protein and significant inhibition of downstream pathways in Karpas 299 cells with an IC50 of 119.33 nM. This compound exhibits antitumor activity.
Smiles
N1=CC=CN1C=2C=CC(=CC2)C3=NC(=C(O3)C)CN4CCC5(C=6C=CC=CC6CC5)CC4
Molecular Formula
C50H60ClN9O7S
Molecular Weight
966.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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