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PROTAC SMARCA2 degrader-12

CAT: 0931-T200633-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200633-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2568277-42-7
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
SMARCA2 degrader-13 (compound I-406) acts as a PROTAC degrader targeting SMARCA2. It exhibits a DC50 of less than 100 nM for the degradation of SMARCA2 protein in A549 cells, achieving a maximum degradation rate (Dmax%) of over 90% after 24 hours of treatment.
Smiles
NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)C=5CC[C@H](C(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CC5)C=C(N=N1)C9=C(O)C=CC=C9
Molecular Formula
C49H57N11O5S
Molecular Weight
912.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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