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HDAC8-IN-12

CAT: 0931-T200383-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200383-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3028095-13-5
Target
HDAC
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
HDAC8-IN-12 (compound 5k), a non-hydroxamic acid derivative, serves as a selective HDAC8 inhibitor with an IC 50 of 0.12 nM and demonstrates potent efficacy against breast cancer. This compound enhances anti-tumor immunity by activating T cells, elevating M1 macrophage levels, and reducing M2 macrophage proportions. In an orthotopic mouse model of breast cancer, HDAC8-IN-12, administered at 50 mg/kg, effectively suppresses tumor growth.
Smiles
O=C(C=CC1=CC=C(C=C1OC)C=C2C(=O)NCC(=O)N2C)NO
Molecular Formula
C16H17N3O5
Molecular Weight
331.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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