ONO-7579

• Target :

  Trk receptor

• Related Pathways :

  Tyrosine Kinase/Adaptors

• Bioactivity :

  ONO-7579, an orally active TRKA inhibitor, effectively suppresses tumor growth by inhibiting TRKA phosphorylation. In KM12 colorectal cancer cells, it exhibits an EC 50 of 17.6 ng/g, indicating that a concentration of 17.6 ng per gram of tumor tissue reduces the activity of phosphorylated TRKA by 50%. This compound is utilized in cancer research.

• Smiles :

  O=C(NC1=CN=C(N=C1)OC=2C=CC(=CC2)C3=CC(Cl)=CN=C3N)NC4=CC(=CC=C4S(=O)(=O)C)C(F)(F)F

• Molecular Formula :

  C24H18ClF3N6O4S

• Molecular Weight :

  578.95

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1622212-25-2