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ONO-7579

CAT: 0931-T200301-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T200301-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1622212-25-2
Target
Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
ONO-7579, an orally active TRKA inhibitor, effectively suppresses tumor growth by inhibiting TRKA phosphorylation. In KM12 colorectal cancer cells, it exhibits an EC 50 of 17.6 ng/g, indicating that a concentration of 17.6 ng per gram of tumor tissue reduces the activity of phosphorylated TRKA by 50%. This compound is utilized in cancer research.
Smiles
O=C(NC1=CN=C(N=C1)OC=2C=CC(=CC2)C3=CC(Cl)=CN=C3N)NC4=CC(=CC=C4S(=O)(=O)C)C(F)(F)F
Molecular Formula
C24H18ClF3N6O4S
Molecular Weight
578.95
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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