ONO-2920632

• Target:

  Potassium Channel

• Related Pathways:

  Membrane transporter/Ion channel

• Bioactivity:

  ONO-2920632 is an orally active and CNS-penetrant TREK channel activator with EC50 values of 0.3?µM for TREK-1 and 2.8?µM for TREK-2. It demonstrates selectivity for other K2P channels, showing over 91-fold selectivity against TASK1, TASK2, TASK3, TRAAK, TWIK2, and 31-fold selectivity against TRESK. ONO-2920632 exhibits analgesic effects and is used in the study of pain, migraine, and neurological disorders.

• Smiles:

  O=C (NCC1=CC=C (OC (F) (F) F) C=C1F) C=2C=CC3=NC=NN3C2

• Molecular Formula:

  C15H10F4N4O2

• Molecular Weight:

  354.259

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2230296-66-7