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Native Human CA153 Protein

CAT: 1510-BNP1032Size: 50 KUDry Ice: NoHazardous: No
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CAT#:1510-BNP1032Size:50 KU
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CA 15-3, for Carcinoma Antigen 15-3, is a tumor marker for many types of cancer, most notably breast cancer. It is derived from MUC1. CA 15-3 and associated CA 27-29 are different epitopes on the same protein antigen product of the breast cancer-associated MUC1 gene. Elevated CA15-3, in conjunction with alkaline phosphatase (ALP), was found to be associated with an increased chance of early recurrence in breast cancer. Both CA 15-3 and CA 27-29 may be elevated in patients with benign ovarian cysts, benign breast disease, and benign liver disease. Elevations may also be seen in cirrhosis, sarcoidosis and lupus.
Description
Purified human Cancer Antigen CA15-3 protein.
Synonyms
KL-6, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, Breast carcinoma associated antigen DF3, CA15-3 antigen, CA15.3, Carcinoma associated mucin, CD 227, CD227, CD227 antigen, DF3 antigen, EMA, Episialin, Epithelial membrane antigen, Epithelial mucin tandem repeat sequence, H23 antigen, H23AG, MAM6, MUC 1, MUC-1, Mucin 1, Mucin 1 precursor, Mucin1, Peanut reactive urinary mucin, PEM, PEMT, Polymorphic epithelial mucin, PUM, Tumor associated epithelial membrane antigen, Tumor associated mucin
Source
Human fluid
Applications
SDS-PAGE
Purity
>60% by SDS-PAGE
Buffer
Each vial contains 10 mM PBS, pH 7.4±0.2 with 0.2% NaN3.
References & Citations
1. Duffy MJ, Duggan C, Keane R, et al. (March 2004) . "High preoperative CA 15-3 concentrations predict adverse outcome in node-negative and node-positive breast cancer: study of 600 patients with histologically confirmed breast cancer". Clin. Chem. 50 (3) : 559–63. 2. Bearz A, Talamini R, Vaccher E, et al. (2007) . "MUC-1 (CA 15-3 antigen) as a highly reliable predictor of response to EGFR inhibitors in patients with bronchioloalveolar carcinoma: an experience on 26 patients". Int. J. Biol. Markers. 22 (4) : 307–11.
Storage Conditions
Shipat 4°C. Upon receipt, aliquot andstore at -20°C for long term. Avoid repeated freeze and thaw cycles.
Formulation
Liquid

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