Native Human CA153 Protein

• Background:

  CA 15-3, for Carcinoma Antigen 15-3, is a tumor marker for many types of cancer, most notably breast cancer. It is derived from MUC1. CA 15-3 and associated CA 27-29 are different epitopes on the same protein antigen product of the breast cancer-associated MUC1 gene. Elevated CA15-3, in conjunction with alkaline phosphatase (ALP), was found to be associated with an increased chance of early recurrence in breast cancer. Both CA 15-3 and CA 27-29 may be elevated in patients with benign ovarian cysts, benign breast disease, and benign liver disease. Elevations may also be seen in cirrhosis, sarcoidosis and lupus.

• Description:

  Purified human Cancer Antigen CA15-3 protein.

• Synonyms:

  KL-6, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, Breast carcinoma associated antigen DF3, CA15-3 antigen, CA15.3, Carcinoma associated mucin, CD 227, CD227, CD227 antigen, DF3 antigen, EMA, Episialin, Epithelial membrane antigen, Epithelial mucin tandem repeat sequence, H23 antigen, H23AG, MAM6, MUC 1, MUC-1, Mucin 1, Mucin 1 precursor, Mucin1, Peanut reactive urinary mucin, PEM, PEMT, Polymorphic epithelial mucin, PUM, Tumor associated epithelial membrane antigen, Tumor associated mucin

• Source:

  Human fluid

• Applications:

  SDS-PAGE

• Purity:

  >60% by SDS-PAGE

• Buffer:

  Each vial contains 10 mM PBS, pH 7.4±0.2 with 0.2% NaN3.

• References & Citations:

  1. Duffy MJ, Duggan C, Keane R, et al. (March 2004) . "High preoperative CA 15-3 concentrations predict adverse outcome in node-negative and node-positive breast cancer: study of 600 patients with histologically confirmed breast cancer". Clin. Chem. 50 (3) : 559–63. 2. Bearz A, Talamini R, Vaccher E, et al. (2007) . "MUC-1 (CA 15-3 antigen) as a highly reliable predictor of response to EGFR inhibitors in patients with bronchioloalveolar carcinoma: an experience on 26 patients". Int. J. Biol. Markers. 22 (4) : 307–11.

• Storage Conditions:

  Shipat 4°C. Upon receipt, aliquot andstore at -20°C for long term. Avoid repeated freeze and thaw cycles.

• Formulation:

  Liquid