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Native Human Thyroglobulin Protein

CAT: 1510-BNP1038Size: 100 μgDry Ice: NoHazardous: No
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CAT#:1510-BNP1038Size:100 μg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin protein accounts for approximately half of the protein content of the thyroid gland. Human TG is a homodimer of subunits each containing 2768 amino acids as synthesized (a short signal peptide may be removed from the N-terminus in the mature protein) . Tg is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3) . Thyroglobulin has been shown to interact with Binding immunoglobulin protein.
Description
Purified human thyroglobulin protein.
Synonyms
Thyroglobulin, TG, AITD 3, AITD3, hTG, TDH3, Tg, TGN, THYG.
Source
Human Thyroid tissue
Applications
SDS-PAGE; ELISA
Purity
>95% by SDS-PAGE
Buffer
Each vial contains 10 mM PBS, pH7.4 with 0.02% NaN3.
References & Citations
Delom F, Mallet B, Carayon P, Lejeune PJ (June 2001) . "Role of extracellular molecular chaperones in the folding of oxidized proteins. Refolding of colloidal thyroglobulin by protein disulfide isomerase and immunoglobulin heavy chain-binding protein". J. Biol. Chem. 276 (24) : 21337–42. Delom F, Lejeune PJ, Vinet L, Carayon P, Mallet B (February 1999) . "Involvement of oxidative reactions and extracellular protein chaperones in the rescue of misassembled thyroglobulin in the follicular lumen". Biochem. Biophys. Res. Commun. 255 (2) : 438–43.
Storage Conditions
Shipat 4°C. Upon receipt, aliquot andstore at -20°C for long term. Avoid repeated freeze and thaw cycles.
Formulation
Liquid

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