D-dimer Protein (Native)

• Background:

  D-dimer is a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two crosslinked D fragments of the fibrin protein. The D-dimer antigen is a unique marker of fibrin degradation that is formed by the sequential action of 3 enzymes: thrombin, factor XIIIa, and plasmin. Its concentration may be determined by a blood test to help diagnose thrombosis. Since its introduction in the 1990s, it has become an important test performed in patients suspected of thrombotic disorders. While a negative result practically rules out thrombosis, a positive result can indicate thrombosis but does not rule out other potential causes. Its main use, therefore, is to exclude thromboembolic disease where the probability is low. In addition, it is used in the diagnosis of the blood disorder disseminated intravascular coagulation.

• Description:

  Native human D-dimer protein.

• Source:

  Human plasma

• Applications:

  ELISA

• Purity:

  >85% by SDS-PAGE

• Buffer:

  0.01 M PBS, 10mM Tris, QM08 Protein stabilizer, 0.1% Proclin300.

• References & Citations:

  Adam SS, Key NS, Greenberg CS (March 2009) . "D-dimer antigen: current concepts and future prospects". Blood 113 (13) : 2878–2887.

• Storage Conditions:

  Shipat 4°C. Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.

• Formulation:

  Liquid