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Recombinant human DUSP26 protein

CAT: 0112-ATGP2324-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2324-020Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DuSP26 inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. This protein inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. DuSP26 can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK) . Recombinant human DuSP26 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Name Alternative
Dual specificity protein phosphatase 26, Dual specificity phosphatase SKRP3, Low-molecular-mass dual-specificity phosphatase 4, DSP-4, LDP-4, Mitogen-activated protein kinase phosphatase 8, MAP kinase phosphatase 8, MKP-8, Novel amplified gene in thyroid anaplastic cancer, Neuroendocrine-associated phosphatase, DUSP24, LDP4, MKP8, NATA1, SKRP3, NEAP
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
26.3 kDa (234aa)
Additionnal Information
DuSP26, Dual specificity protein phosphatase 26, Dual specificity protein phosphatase 26, Dual specificity phosphatase 26 (putative), DuSP24, LDP-4, MKP8, NATA1, SKRP3, ATGP2324-10 µg, ATGP2324-20 µg, ATGP2324-50 µg, ATGP2324-100 µg, ATGP2324-250 µg, ATGP2324-500 µg, ATGP2324-1 mg, ATGP2324-10, ATGP2324-20, ATGP2324-50, ATGP2324-100, ATGP2324-250, ATGP2324-500, ATGP2324-1
References & Citations
Vasudevan S.A.. et al. (2005) . Biochem. Biophys. Res. Commun. 330:511-518; ; Yu W., et al. (2007) . Oncogene 26:1178-1187;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Scientific Category
Signal Transduction
NCBI Accession Number
NP_076930
Uniprot Accession Number
Q9BV47
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMCPGNWL WASMTFMARF SRSSSRSPVR TRGTLEEMPT VQHPFLNVFE LERLLYTGKT ACNHADEVWP GLYLGDQDMA NNRRELRRLG ITHVLNASHS RWRGTPEAYE GLGIRYLGVE AHDSPAFDMS IHFQTAADFI HRALSQPGGK ILVHCAVGVS RSATLVLAYL MLYHHLTLVE AIKKVKDHRG IIPNRGFLRQ LLALDRRLRQ GLEA

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