Products for Research Use Only
RegisterLogin

GNE-9605

CAT: 0804-HY-12282-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-12282-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GNE-9605 is a potent, orally active, selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC50 value of 18.7 nM. GNE-9605 inhibits LRRK2 Ser1292 autophosphorylation. GNE-9605 can be used in research of Parkinson's disease (PD) [1].
CAS Number
1536200-31-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/GNE-9605.html
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C1=CN=C(NC2=C(Cl)N([C@@H]3[C@@H](F)CN(C4COC4)CC3)N=C2)N=C1NC)(F)F
Molecular Formula
C17H20ClF4N7O
Molecular Weight
449.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Estrada AA, et, al. Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57 (3) :921-36. |[2]Kumar S, et, al. Exploring the focal role of LRRK2 kinase in Parkinson's disease. Environ Sci Pollut Res Int. 2022 May;29 (22) :32368-32382.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-175448GNE-1567
HY-15883-01GNE-900
HY-107498-01GNE-8324
HY-141551-01GNE-274
HY-107409-01GNE 5729
HY-19775-01GNE-6468
HY-148238GNE-2256
HY-10811-01GNE-493
HY-18163-01GNE-7915
HY-149026-01GNE-064

Alternative Products

CatalogName
B4761-5GNE-9605
MBS384780-01GNE 9605
A14149-25GNE 9605 25mg
A14149-100GNE 9605 100mg
A14149-10GNE 9605 10mg
A14149-50GNE 9605 50mg
A14149-5GNE 9605 5mg
A14149-2GNE 9605 2mg
A14149-10mM-DGNE 9605 10mM * 1mL in DMSO
400606-01GNE

Popular Products