Sonidegib (diphosphate)

• UNSPSC Description:

  Sonidegib diphosphate (Erismodegib diphosphate) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively[1].

• Target Antigen:

  Smo

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/LDE225-Diphosphate.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 0.25 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C(C)C(C(C=C2)=CC=C2OC(F)(F)F)=CC=C1)NC3=CC=C(N=C3)N4C[C@@H](C)O[C@@H](C)C4.O=P(O)(O)O.O=P(O)(O)O

• Molecular Weight:

  681.49

• References & Citations:

  [1]Pan S, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med Chem Lett. 2010 Mar 16;1(3):130-4.|[2]Irvine DA, et al. Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci Rep. 2016 May 9;6:25476.J Genet Genomics. 2018 May 20;45(5):237-246.|Nat Med. 2018 Nov;24(11):1752-1761. |Patent. US20180263995A1.|bioRxiv. 2023 Nov 6.|bioRxiv. 2024 Jul 25.|bioRxiv. 2024 Oct 9:2024.10.08.617155.|Cell Physiol Biochem. 2018;47(4):1352-1364.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  1218778-77-8