Sonidegib metabolite M48

• UNSPSC Description:

  Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer Tmax (60 h) than Sonidegib[1].

• Target Antigen:

  Drug Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sonidegib-metabolite-m48.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)C1=C(C(C2=CC=C(C=C2)OC(F)(F)F)=CC=C1)C

• Molecular Weight:

  296.244

• References & Citations:

  [1]Markus Zollinger, et al. Absorption, distribution, metabolism, and excretion (ADME) of ¹⁴C-sonidegib (LDE225) in healthy volunteers. Cancer Chemother Pharmacol. 2014 Jul;74(1):63-75.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1221722-10-6