Sonidegib-d4

• Description :

  Sonidegib-d4 is a isotope of Sonidegib. Sonidegib is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively[1].

• Product Name Alternative :

  Erismodegib-d4; LDE225-d4; NVP-LDE225-d4

• UNSPSC :

  12352005

• Target :

  Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Others

• Field of Research :

  Others

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=C(C=CC=C1C2=CC=C(C=C2)OC(F)(F)F)C(NC3=CC=C(N=C3)N4C([2H])([C@@H](O[C@@H](C4([2H])[2H])C)C)[2H])=O

• Molecular Formula :

  C26H22D4F3N3O3

• Molecular Weight :

  489.52

• References & Citations :

  [1]Pan S, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med Chem Lett. 2010 Mar 16;1 (3) :130-4.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported