Sonidegib-d4

• Description:

  Sonidegib-d4 is a isotope of Sonidegib. Sonidegib is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively[1].

• Product Name Alternative:

  Erismodegib-d4; LDE225-d4; NVP-LDE225-d4

• UNSPSC:

  12352005

• Target:

  Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Others

• Field of Research:

  Others

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C (C=CC=C1C2=CC=C (C=C2) OC (F) (F) F) C (NC3=CC=C (N=C3) N4C ([2H]) ([C@@H] (O[C@@H] (C4 ([2H]) [2H]) C) C) [2H]) =O

• Molecular Formula:

  C26H22D4F3N3O3

• Molecular Weight:

  489.52

• References & Citations:

  [1]Pan S, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med Chem Lett. 2010 Mar 16;1 (3) :130-4.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported