PD-334581

• Description :

  PD-334581 is a MEK1 inhibitor[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  MEK

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pd-334581.html

• Purity :

  99.72

• Solubility :

  DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  FC1=C(F)C(NC2=CC=C(C=C2F)I)=C(C3=NN=C(NCCN4CCOCC4)O3)C=C1

• Molecular Formula :

  C20H19F3IN5O2

• Molecular Weight :

  545.30

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Ohren JF, et al. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. 2004 Dec;11 (12) :1192-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MEK1

• CAS Number :

  [548756-68-9]