SY-LB-35

• UNSPSC Description:

  SY-LB-35 is a potent bone morphogenetic protein (BMP) receptor agonist. SY-LB-35 can stimulate significant increases in cell number and cell viability in the C2C12 myoblast cell line, and causes shifts towards the S and G2/M phases of the cell cycle. SY-LB-35 stimulates canonical Smad and non-canonical PI3K/Akt, ERK, p38 and JNK intracellular signaling pathways[1].

• Target Antigen:

  Akt; ERK; JNK; PI3K; TGF-beta/Smad

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt;TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/sy-lb-35.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC1=CC2=C(NC(C3=NC4=CC=CC=C4N3)=C2)C=C1

• Molecular Weight:

  249.27

• References & Citations:

  [1]Najafi S, et al. Discovery of a novel class of benzimidazoles as highly effective agonists of bone morphogenetic protein (BMP) receptor signaling. Sci Rep. 2022 Jul 15;12(1):12146.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2603461-70-5