SY-LB-35

CAT: 0804-HY-150795-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-150795-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SY-LB-35 is a potent bone morphogenetic protein (BMP) receptor agonist. SY-LB-35 can stimulate significant increases in cell number and cell viability in the C2C12 myoblast cell line, and causes shifts towards the S and G2/M phases of the cell cycle. SY-LB-35 stimulates canonical Smad and non-canonical PI3K/Akt, ERK, p38 and JNK intracellular signaling pathways[1].
CAS Number
[2603461-70-5]
UNSPSC
12352005
Target
Akt; ERK; JNK; PI3K; TGF-beta/Smad
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sy-lb-35.html
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC2=C(NC(C3=NC4=CC=CC=C4N3)=C2)C=C1
Molecular Formula
C15H11N3O
Molecular Weight
249.27
References & Citations
[1]Najafi S, et al. Discovery of a novel class of benzimidazoles as highly effective agonists of bone morphogenetic protein (BMP) receptor signaling. Sci Rep. 2022 Jul 15;12 (1) :12146.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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