Products for Research Use Only
RegisterLogin

SY-5102

CAT: 0013-GTR19273983-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19273983-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SY-5102 is a potent, selective, orally active cyclin-dependent kinase (CDK7) inhibitor with a Kd of 0.03 nM. It exhibits antiproliferative activity against HCC70 cells with an EC50 of 9 nM. SY-5102 inhibits CDK7-mediated CAK function [downregulating CDK2Thr160 phosphorylation] and TFIIH transcription function [downregulating RNA polymerase II Ser5 phosphorylation]. The compound induces G2/M cell cycle arrest, downregulates the expression of the oncogene c-Myc, and ultimately triggers apoptosis in cancer cells. SY-5102 is applicable for research in triple-negative breast cancer (TNBC) .
CAS Number
2365230-48-2
Smiles
C (F) (F) (F) C=1C (C=2C=3C (NC2) =NC (=CC3) C=4C (C) =NOC4C) =NC (N[C@H]5CCCNC5) =NC1
Molecular Formula
C22H22F3N7O
Molecular Weight
457.46
Storage Conditions
-20°C
Notes
For research use only.

Related Products

CatalogName
GTR19170833-01SY-640
GTR19191640-01SY-5609
GTR19188048SY-LB-57
GTR19188114SY-LB-35
GTR19288399-01SY-21 NHS ester
GTR19173829-01AZ-5104
GTR19187476-01THK-5105
GTR19187787-01MK-5108
GTR19164087-01MK-5108
GTR19031130-01ABT-510

Alternative Products

CatalogName
HY-180355SY-5102
40105202025102 SP-XUV Spectrophotometer
MBS133151SY-1365
E1041-25mgSY-5609
T37859-01SY-640
BA6437-100SY-LB-35
T60429SY-LB-57

Popular Products