IGF2R/M6PR Polyclonal Antibody, RBITC Conjugated

• Background:

  Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

• Synonyms:

  Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD222; IGF2R; MPRI

• Gene ID:

  3482

• Swiss Prot:

  P11717

• Cellular Locus:

  Cytoplasm, Cell membrane, Extracellular matrix

• Host:

  Rabbit

• Cross Reactivity:

  Human, Mouse

• Immunogen:

  2201-2400/2491

• Target:

  IGF2R/M6PR

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  RBITC

• Source:

  KLH conjugated synthetic peptide derived from human IGF2R/Mannose 6 Phosphate Receptor

• Applications:

  FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification:

  Purified by Protein A.

• Excitation Emission:

  570nm/595nm

• Concentration:

  1µg/µl

• Dilution:

  FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer:

  Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

• Gene ID URL:

  3482

• Predicted Cross Reactivity:

  Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit