SB-525334

CAT: 0498-bs-82623C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82623C-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5), IC50 = 14.3 nM and ALK4 (IC50 = 58.5 nM) with no activity at ALK2, 3 and 61. Blocks fibrosis markers and renal injury in the puromycin-induced nephritis model1. It causes significant attenuation in Smad2/3 nuclear translocation, decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis2. Sensitizes drug-resistant pancreatic cancer cells to gemcitabine3. Cell permeable and active in vivo.
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
-20°C

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MBS3604223-01SB 525334
2880-5SB-525334
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A10827-25SB 525334 25mg
A10827-100SB 525334 100mg
A10827-200SB 525334 200mg
TBI2983-25MGSB-525334, ALK5
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A10827-50SB 525334 50mg

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