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Tesmilifene HCl

CAT: 0498-bs-82057C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82057C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tesmilifene, an analog of tamoxifen, acts as a chemopotentiator and antineoplastic agent and was developed for the treatment of breast cancer but never marketed.1 It binds with high affinity to the anti-estrogen binding site (AEBS) in rat liver microsomes but does not bind to the estrogen receptor (at or below 10 µM) .2 Displaces histamine from AEBS, an activity which correlates with its cytotoxic effects on breast cancer cells.2 Enhances the cytotoxicity of taxol, epirubicin, doxorubicin and vinorelbine in multidrug resistance cell lines.3 It has been shown to increase the permeability of the blood-brain and blood-glioma barrier in culture and animal models by modifying brain endothelial functions.4
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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Alternative Products

CatalogName
HY-13762Tesmilifene
M23352-01Tesmilifene fumarate
202890Tesmilifene HCl
HY-13762STesmilifene-d4
T204127-01Tesmilifene hydrochloride
HY-13762ATesmilifene (hydrochloride)
HY-101179-01Tesmilifene (fumarate)
GTR19154298-01Tesmilifene HCl (DPPE)
HY-101179RTesmilifene (fumarate) (Standard)
TBI1085-10MGTesmilifene HCl (DPPE), Anti-estrogen; Chemo-potentiating agent

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