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Leelamine HCl

CAT: 0498-bs-82616C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82616C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition of autophagic flux.1 Induces apoptosis in breast cancer2, melanoma3 and prostate cancer cells4. A selective inducer of cytochrome P450 2B.5 Inhibits pyruvate dehydrogenase kinase (PDK), IC50=9.5 µM.6
Conjugation
Unconjugated
Buffer
Off-white or beige solid
Storage Conditions
-20°C

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