BRAF Mouse Monoclonal Antibody

• Background:

  This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.

• Product Name Alternative:

  Serine/threonine-protein kinase B-raf, Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1, BRAF, BRAF1, RAFB1

• Gene Name:

  BRAF

• Gene ID:

  673

• Swiss Prot:

  P15056

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, ICC

• Field of Research:

  MAPK signaling pathway

• Purification:

  Affinity Purification

• Dilution:

  WB 1:500-1:2000, ICC 1:20-1:50

• Form:

  Liquid

• Buffer:

  Purified antibody in TBS with 0.05% sodium azide.

• Modification:

  Unmodified

• Molecular Weight:

  84.4kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Isotype:

  Mouse IgG1