BRAF Mouse Monoclonal Antibody

• Background:

  Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations.

• Product Name Alternative:

  BRAF; BRAF1; RAFB1; Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1

• Gene Name:

  BRAF

• Gene ID:

  673

• Swiss Prot:

  P15056

• Host:

  Mouse

• Reactivity:

  Human, Mouse

• Clonality:

  Monoclonal

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  MAPK signaling pathway

• Purification:

  Affinity Purification

• Dilution:

  WB 1:500-1:1000

• Form:

  Liquid

• Buffer:

  Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

• Modification:

  Unmodified

• Molecular Weight:

  Calculated MW: 84 kDa; Observed MW: 87 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Isotype:

  Mouse IgG2a