BRAF Mouse Monoclonal Antibody

• Background:

  This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

• Product Name Alternative:

  NS7; B-raf; BRAF1; RAFB1; B-RAF1

• Gene Name:

  BRAF

• Gene ID:

  673

• Swiss Prot:

  P15056

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Monkey

• Clonality:

  Monoclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC, ELISA, FC

• Field of Research:

  MAPK signaling pathway

• Purification:

  Affinity Purification

• Dilution:

  WB 1:500-1:2000, IHC 1:200-1:1000, ELISA 1:5000-1:20000, FC 1:200-1:400

• Form:

  Liquid

• Buffer:

  Purified antibody in PBS with 0.05% sodium azide

• Modification:

  Unmodified

• Molecular Weight:

  84.4kda

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Isotype:

  Mouse IgG1