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M435-1279

CAT: 0804-HY-141891-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-141891-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1[1].
CAS Number
1359431-16-5
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; Wnt
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m435-1279.html
Purity
98.43
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C(O)C2=C(SC3=C2CCCC3)NC1=O)NC4=CC=C(S(=O)(N)=O)C=C4
Molecular Formula
C18H17N3O5S2
Molecular Weight
419.47
References & Citations
[1]Yu Z, et al. A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination. Oncogene. 2021 Feb;40 (5) :1027-1042. doi: 10.1038/s41388-020-01572-w. Epub 2020 Dec 15. Erratum in: Oncogene. 2021 Apr;40 (14) :2622-2623.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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