Naphazoline

• UNSPSC Description:

  Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline can be used for non-bacterial conjunctivitis research[1][2].

• Target Antigen:

  Adrenergic Receptor; Interleukin Related; TNF Receptor; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/naphazoline.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C1(CC2=C3C=CC=CC3=CC=C2)=NCCN1

• Molecular Weight:

  210.27

• References & Citations:

  [1]Quan L, et, al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. Mol Med Rep. 2016 Apr;13(4):3319-25.|[2]Yamaguchi I, et, al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203(1):125-31.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  835-31-4