Naphazoline

• Description :

  Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline can be used for non-bacterial conjunctivitis research[1][2].

• Product Name Alternative :

  Naphthazoline

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Adrenergic Receptor; Interleukin Related; TNF Receptor; VEGFR

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/naphazoline.html

• Purity :

  99.74

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles :

  C1(CC2=C3C=CC=CC3=CC=C2)=NCCN1

• Molecular Formula :

  C14H14N2

• Molecular Weight :

  210.27

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Quan L, et, al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. Mol Med Rep. 2016 Apr;13 (4) :3319-25.|[2]Yamaguchi I, et, al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203 (1) :125-31.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  IL-1; IL-4; IL-6; TNFRSF5/CD40

• CAS Number :

  [835-31-4]