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MKK7-COV-9

CAT: 0804-HY-122872-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122872-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein-protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC50 of 4.98 μM[1].
CAS Number
2283355-59-7
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mkk7-cov-9.html
Purity
97.69
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC)C1=CC(NC(C=C)=O)=CC(C2=NNC3=C2C=CC=C3)=C1
Molecular Formula
C18H16N4O2
Molecular Weight
320.35
References & Citations
[1]Amit Shraga, et al. Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor. Cell Chem Biol. 2019 Jan 17;26 (1) :98-108.e5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38 MAPK

Chemical Information

Mkk7-cov-9
CAS Number2283355-59-7
PubChem CID137796287
IUPAC Name3-(1H-indazol-3-yl)-N-methyl-5-(prop-2-enoylamino)benzamide
Molecular FormulaC18H16N4O2
Molecular Weight320.3
XLogP2.3
Topological Polar Surface Area86.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity495
SMILES
CNC(=O)C1=CC(=CC(=C1)C2=NNC3=CC=CC=C32)NC(=O)C=C
InChI
InChI=1S/C18H16N4O2/c1-3-16(23)20-13-9-11(8-12(10-13)18(24)19-2)17-14-6-4-5-7-15(14)21-22-17/h3-10H,1H2,2H3,(H,19,24)(H,20,23)(H,21,22)
InChIKey
OIVBYXJDKPKZFE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mkk7-cov-9
CAS: 2283355-59-7
CID: 137796287
Formula: C18H16N4O2
MW: 320.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight320.3
XLogP32.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass320.12732577
Monoisotopic Mass320.12732577
Topological Polar Surface Area86.9 Ų
Heavy Atom Count24
Formal Charge0
Complexity495
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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