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MKK7-JNK activator 1

CAT: 0804-HY-179044Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179044Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator. MKK7-JNK activator 1 effectively inhibits the proliferation and migration of MDA-MB-468 cells, induces G2/M phase arrest and caspase -dependent apoptosis (independent of ROS production) . MKK7-JNK activator 1 significantly increases the levels of p-MKK7 and p-JNK, but does not affect p-ERK or p-p38. MKK7-JNK activator 1 can be used for the study of triple-negative breast cancer (TNBC) [1].
CAS Number
3100092-62-1
UNSPSC
12352005
Target
Apoptosis; Caspase; JNK; p38 MAPK
Related Pathways
Apoptosis; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
CC1=NC2=C(OCC3=CC=CC(I)=C3)C(Br)=CC(Br)=C2C=C1
Molecular Formula
C17H12Br2INO
Molecular Weight
533.00
References & Citations
[1]Ma L, et al. Synthesis and evaluation of 8- (benzyloxy) -5,7-dibromo-2-methylquinoline derivatives as inducers of apoptosis in triple-negative breast cancer MDA-MB-468 cells via MKK7-JNK pathway activation. Bioorg Chem. 2025 Oct 17;166:109117.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 8; Caspase 9

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MBS6469067-01CIKS, CT (Connection to IKK and SAPK, JNK, Act1, NF-kB Activator 1) (Biotin)
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