MERS-CoV-IN-2

MERS-CoV-IN-2

• UNSPSC Description: MERS-CoV-IN-2 (compound 3c) is a MERS-CoV 3CLpro inhibitor (IC50=17nM). MERS-CoV-IN-2 inhibits the activity of the 3CLpro enzyme by binding to the active site of the enzyme, specifically the S4 subsite, thereby exhibiting antiviral activity against SARS-CoV-2 and MERS-CoV[1].
• Target Antigen: SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/mers-cov-in-2.html
• Smiles: O=C(N[C@H](C(N[C@H](C=O)C[C@H]1C(NCC1)=O)=O)CC(C)C)OC[C@@H](N2CC3=CC=CC(Cl)=C3)CCC2=O
• Molecular Weight: 535.03
• References & Citations: [1]Dampalla, et al. Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies. Journal of Medicinal Chemistry (2024).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported