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SARS-CoV-IN-6

CAT: 0804-HY-162924Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162924Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SARS-CoV-IN-6 (Compound 17) is an inhibitor of SARS-CoV-1 and SARS-CoV-2 RdRp, with an IC50 value of 7.8 μM against SARS-CoV-2 RdRp. SARS-CoV-IN-6 reduces cytopathic effects in cells infected with SARS-CoV-1 and SARS-CoV-2 replicon-based single-round infectious particles (SRIPs), and inhibits SARS-CoV N protein expression, with EC50 values of 0.12 µM for SARS-CoV-1 replicon-based SRIPs and 1.47 µM for SARS-CoV-2 replicon-based SRIPs[1].
CAS Number
2244671-47-2
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sars-cov-in-6.html
Smiles
CN1C(N(C)C=C(CNC2=CC=C3N(C[C@H]4C[C@@H]3CN(CC5=CC=CC=C5)C4)C2=O)C1=O)=O
Molecular Formula
C25H29N5O3
Molecular Weight
447.53
References & Citations
[1]Chen Y, et al. Assessing the inhibitory effects of some secondary amines, thioureas and 1,3-dimethyluracil conjugates of (-) -cytisine and thermopsine on the RNA-dependent RNA polymerase of SARS-CoV-1 and SARS-CoV-2. Bioorg Med Chem Lett. 2024 Sep 7;113:129950.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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